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KMID : 0923620200200050041
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Immune Network
2020 Volume.20 No. 5 p.41 ~ p.41
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The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene
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Kim Sin-Ae
Lee Jong-Ho
Lee Si-Young
Shim Sae-Rok
Nguyen Tam T.
Hwang Ji-Hyeong
Kim Hei-Jun
Choi Yeo-Ok
Hong Jae-Woo
Bae Su-Young
Jhun Hyun-Jhung
Yum Ho-Kee
Lee Young-Min
Chan Edward D.
Yu Liping
Azam Tania
Kim Yong-Dae
Yeom Su-Cheong
Yoo Kwang-Ha
Kang Lin-Woo
Shin Kyeong-Cheol
Kim Soo-Hyun
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Abstract
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a positive-sense single-stranded RNA (+ssRNA) that causes coronavirus disease 2019 (COVID-19). The viral genome encodes twelve genes for viral replication and infection. The third open reading frame is the spike (S) gene that encodes for the spike glycoprotein interacting with specific cell surface receptor ? angiotensin converting enzyme 2 (ACE2) ? on the host cell membrane. Most recent studies identified a single point mutation in S gene. A single point mutation in S gene leading to an amino acid substitution at codon 614 from an aspartic acid 614 into glycine (D614G) resulted in greater infectivity compared to the wild type SARS-CoV2. We were interested in investigating the mutation region of S gene of SARS-CoV2 from Korean COVID-19 patients. New mutation sites were found in the critical receptor binding domain (RBD) of S gene, which is adjacent to the aforementioned D614G mutation residue. This specific sequence data demonstrated the active progression of SARS-CoV2 by mutations in the RBD of S gene. The sequence information of new mutations is critical to the development of recombinant SARS-CoV2 spike antigens, which may be required to improve and advance the strategy against a wide range of possible SARS-CoV2 mutations.
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KEYWORD
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SARS coronavirus 2, Spike glycoprotein, COVID-19 receptor binding domain, COVID-19 mutation, COVID-19 antigens
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